The genetic material is the substrate of transactions such as transcription and replication, which engender the risk of creating lesions on it. Moreover, the DNA is exposed to both external and internal sources of damage. In all of these instances, the cell sets into action surveillance and repair mechanisms to preserve the integrity of the genome. All these events take place within the nucleus of the cell, and therefore much attention and research efforts have been devoted to deeply understand these nuclear mechanisms. Yet, the nucleus is embedded in the cytoplasm, and recent investigations start to shed light onto the impact that processes up-to-here considered to be exclusively cytoplasmic may have on the organization, maintenance and dynamics of the genome. The aim of our team is to enlarge our knowledge of how nutritional setups, environmental cues and metabolic alterations affect or even control genome integrity maintenance. To tackle these issues, we take advantage of S. cerevisiaeand cultured human cells as model systems and utilize a combination of Genetics, Molecular Biology, Biochemistry and Fluorescence Microscopy.
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Members of the team
(Research Assistant) +33 (0)4 34 35 95 64
(Staff Scientist) +33 (0)4 34 35 95 64
(Research Assistant) +33 (0)4 34 35 9