Cytoplasmic control of genome stability

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The genetic material is the substrate of transactions such as transcription and replication, which engender the risk of creating lesions on it. Moreover, the DNA is exposed to both external and internal sources of damage. In all of these instances, the cell sets into action surveillance and repair mechanisms to preserve the integrity of the genome. All these events take place within the nucleus of the cell, and therefore much attention and research efforts have been devoted to deeply understand these nuclear mechanisms. Yet, the nucleus is embedded in the cytoplasm, and recent investigations start to shed light onto the impact that processes up-to-here considered to be exclusively cytoplasmic may have on the organization, maintenance and dynamics of the genome. The aim of our team is to enlarge our knowledge of how nutritional setups, environmental cues and metabolic alterations affect or even control genome integrity maintenance. To tackle these issues, we take advantage of S. cerevisiaeand cultured human cells as model systems and utilize a combination of Genetics, Molecular Biology, Biochemistry and Fluorescence Microscopy.

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Maria Moriel-Carretero

Members of the team

  • Jocelyn COIFFARD
    (Trainee) +33 (0)4 34 35 95 64
  • Manon GARCIA
    (Trainee) +33 (0)4 34 35 9
  • Sylvain KUMANSKI
    (Research Assistant) +33 (0)4 34 35 96 83
  • Maria MORIEL Group Leader
    (Staff Scientist) +33 (0)4 34 35 95 64
  • Olivier SANTT
    (Staff Scientist) +33 (0)4 34 35 96 83
  • Caroline SOULET
    (Research Assistant) +33 (0)4 34 35 96 83
    • 2020

      Homologous Recombination and Mus81 Promote Replication Completion in Response to Replication Fork Blockage

      Benjamin Pardo, María Moriel-Carretero, Thibaud Vicat, Andrés Aguilera , Philippe Pasero

      EMBO Rep. 17;e49367 Pubmed

    • 2020

      The Hypothetical Role of Phosphatidic Acid in Subverting ER Membranes During SARS-CoV Infection

      María Moriel-Carretero

      Traffic . 2020 May 18. doi: 10.1111/tra.12738 Pubmed

    • 2019

      PyFuncover: full proteome search for a specific function using BLAST and PFAM

      Yoan Bouzin, Benjamin Thomas Viart, María Moriel-Carretero, Sofia Kossida

      EMBnet.journal 24, e925 Pubmed

    The team in March 2019