Our Research

We use bioinformatics and theoretical structural biology methods to understand the principles of protein structure and biomolecular interactions. Today, bioinformatics plays an increasingly important role in biological research. The mass of genome sequencing data significantly exceeds the development of our data analysis capacity. The dramatic growth of genomic data presents new challenges for scientists. Indeed, making sense of millions of protein sequences requires systematic approaches and information about their 3D structure as well as their evolutionary and functional relationships. In line with this tendency, we focus on developing bioinformatics tools for the large-scale, structural and functional annotation of proteomes.

We are particularly interested in:

Proteins with tandem repeats

We pioneered the bioinformatics analysis, classification, structural prediction and modelling of proteins with repeats that fold into a solenoid-like arrangement. Further development of reliable methods for the identification of repetitive protein motifs and the ab initio prediction of their 3D structures promises to be a fertile research field in structural bioinformatics. Over the last years, many evidences have been accumulated about the high incidence of tandem repeats in the amino acid sequences of virulence factors of pathogens and of some amyloidogenic proteins and prions. Thus, the discovery and structure-function predictions of these domains could lead to the identification of targets for new drugs and vaccines against emerging infectious diseases and to the development of amyloidogenesis inhibitors.

Amyloides and Prions

Several lines of evidence suggest that amyloid fibrils play a causative role in several neurodegenerative diseases, including Alzheimer’s, Parkinson’s and Huntington’s disease. The determination of the fibril structure goes through the prediction of structural models based on the accumulated experimental evidences, until a unique model can explain the whole set of data. We are contributing to this progress by developing structural models for the amyloid and prion fibrils. Our ultimate goals are the structure-based prediction of the amyloidogenic properties of amino acid sequences and the rational design of fibrillogenesis inhibitors.

To access our bioinformatics tools go to : http://bioinfo.montp.cnrs.fr/

National Institute of Health (Andrei KAjava)

Commission Européenne (Andrei KAjava & Bernardo Pau)


  • AmyloComp: A Bioinformatic Tool for Prediction of Amyloid Co-aggregation. Bondarev SA, Uspenskaya MV, Leclercq J, Falgarone T, Zhouravleva GA, Kajava AV.  J Mol Biol. 2024 Jan 5:168437. Pubmed


  • A STRP-ed definition of Structured Tandem Repeats in Proteins. Monzon AM, Arrías PN, Elofsson A, Mier P, Andrade-Navarro MA, Bevilacqua M, Clementel D, Bateman A, Hirsh L, Fornasari MS, Parisi G, Piovesan D, Kajava AV, Tosatto SCE.  J Struct Biol. 2023 Aug 29;215(4):108023. Pubmed
  • The repetitive structure of DNA clamps: An overlooked protein tandem repeat. Arrías PN, Monzon AM, Clementel D, Mozaffari S, Piovesan D, Kajava AV, Tosatto SCE.  J Struct Biol. 2023 Sep;215(3):108001.. Pubmed
  • Why does the first protein repeat often become the only one? Manasra S, Kajava AV.  J Struct Biol. 2023 Sep;215(3):108014. Pubmed
  • Census of exposed aggregation-prone regions in proteomes. Falgarone T, Villain E, Richard F, Osmanli Z, Kajava AV.  Brief Bioinform. 2023 Jul 20;24(4):bbad183. Pubmed
  • ATR-FTIR spectrum analysis of plasma samples for rapid identification of recovered COVID-19 individuals. Karas BY, Sitnikova VE, Nosenko TN, Dedkov VG, Arsentieva NA, Gavrilenko NV, Moiseev IS, Totolian AA, Kajava AV, Uspenskaya MV.  J Biophotonics. 2023 Jul;16(7):e202200166. Pubmed
  • Pathogenic TRIO variants associated with neurodevelopmental disorders perturb the molecular regulation of TRIO and axon pathfinding in vivo.Bonnet M, Roche F, Fagotto-Kaufmann C, Gazdagh G, Truong I, Comunale F, Barbosa S, Bonhomme M, Nafati N, Hunt D, Rodriguez MP, Chaudhry A, Shears D, Madruga M, Vansenne F, Curie A, Kajava AV, Baralle D, Fassier C, Debant A, Schmidt S.  Mol Psychiatry. 2023 Apr;28(4):1527-1544. Pubmed


  • Molecular Determinants of Fibrillation in a Viral Amyloidogenic Domain from Combined Biochemical and Biophysical Studies. Nilsson JF, Baroudi H, Gondelaud F, Pesce G, Bignon C, Ptchelkine D, Chamieh J, Cottet H, Kajava AV, Longhi S.  Int J Mol Sci. 2022 Dec 26;24(1):399. Pubmed
  • The Difference in Structural States between Canonical Proteins and Their Isoforms Established by Proteome-Wide Bioinformatics Analysis. Osmanli Z, Falgarone T, Samadova T, Aldrian G, Leclercq J, Shahmuradov I, Kajava AV. Biomolecules. 12(11):1610. Pubmed
  • A structural biology community assessment of AlphaFold2 applications. Akdel M, Pires DEV, Pardo EP, Jänes J, Zalevsky AO, Mészáros B, Bryant P, Good LL, Laskowski RA, Pozzati G, Shenoy A, Zhu W, Kundrotas P, Serra VR, Rodrigues CHM, Dunham AS, Burke D, Borkakoti N, Velankar S, Frost A, Basquin J, Lindorff-Larsen K, Bateman A, Kajava AV, Valencia A, Ovchinnikov S, Durairaj J, Ascher DB, Thornton JM, Davey NE, Stein A, Elofsson A, Croll TI, Beltrao P. Nat Struct Mol Biol. 29(11):1056-1067. Pubmed
  • A SARS-CoV-2 Spike Receptor Binding Motif Peptide Induces Anti-Spike Antibodies in Mice and Is Recognized by COVID-19 Patients. Pratesi F, Errante F, Pacini L, Peña-Moreno IC, Quiceno S, Carotenuto A, Balam S, Konaté D, Diakité MM, Arévalo-Herrera M, Kajava AV, Rovero P, Corradin G, Migliorini P, Papini AM, Herrera S. Front Immunol. 13:879946. Pubmed
  • Predicting Protein Conformational Disorder and Disordered Binding Sites. Tamburrini KC, Pesce G, Nilsson J, Gondelaud F, Kajava AV, Berrin JG, Longhi S. Methods Mol Biol. 2449:95-147. Pubmed
  • TAPASS: Tool for annotation of protein amyloidogenicity in the context of other structural states. Falgarone T, Villain É, Guettaf A, Leclercq J, Kajava AV. J Struct Biol. 214(1):107840. Pubmed
  • The C-terminal segment of Leishmania major HslU: Toward potential inhibitors of LmHslVU activity. Singh P, Samanta K, Kebe NM, Michel G, Legrand B, Sitnikova VE, Kajava AV, Pagès M, Bastien P, Pomares C, Coux O, Hernandez JF. Bioorg Chem. 119:105539. Pubmed
  • Aspartate-phobia of thermophiles as a reaction to deleterious chemical transformations. Villain E, Fort P, Kajava AV. Bioessays. 44(1):e2100213. Pubmed


  • Identification of a Region in the Common Amino-terminal Domain of Hendra Virus P, V, and W Proteins Responsible for Phase Transition and Amyloid Formation. Salladini E, Gondelaud F, Nilsson JF, Pesce G, Bignon C, Murrali MG, Fabre R, Pierattelli R, Kajava AV, Horvat B, Gerlier D, Mathieu C, Longhi S. Biomolecules 1, 1324 Pubmed
  • Critical assessment of protein intrinsic disorder prediction. Necci M, Piovesan D; CAID Predictors; DisProt Curators, Tosatto SCE. Nat Methods. 18(5):472-481. Pubmed
  • RepeatsDB in 2021: improved data and extended classification for protein tandem repeat structures. Paladin L, Bevilacqua M, Errigo S, Piovesan D, Mičetić I, Necci M, Monzon AM, Fabre ML, Lopez JL, Nilsson JF, Rios J, Menna PL, Cabrera M, Buitron MG, Kulik MG, Fernandez-Alberti S, Fornasari MS, Parisi G, Lagares A, Hirsh L, Andrade-Navarro MA, Kajava AV, Tosatto SCE. Nucleic Acids Res. 49(D1):D452-D457 Pubmed


  • Estimation of amyloid aggregate sizes with semi-denaturing detergent agarose gel electrophoresis and its limitations. Skitchenko RK, Rogoza TM, Leclercq JY, Kajava AV, Matveenko AG, Zhouravleva GA, Bondarev SA. Prion. 14(1):118-128. Pubmed
  • Trimeric SARS-CoV-2 Spike Proteins Produced from CHO Cells in Bioreactors Are High-Quality Antigens. P. Pino, J. Kint, D. Kiseljak, V. Agnolon, G. Corradin, A. V. Kajava, P. Rovero, R. Dijkman, G. den Hartog,[…] Processes, 8(12), 1539 Pubmed
  • Multifunctional Amyloid Oligomeric Nanoparticles for Specific Cell Targeting and Drug Delivery. Wang W, Azizyan RA, Garro A, Kajava AV, Ventura S. Biomacromolecules. 21(10):4302-4312. Pubmed
  • Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes. Sleiman Y, Souidi M, Kumar R, Yang E, Jaffré F, Zhou T, Bernardin A, Reiken S, Cazorla O, Kajava AV, Moreau A, Pasquié JL, Marks AR, Lerman BB, Chen S, Cheung JW, Evans T, Lacampagne A, Meli AC. 60:103024. Pubmed
  • Amyloidogenicity as a driving force for the formation of functional oligomers. Azizyan RA, Wang W, Anikeenko A, Radkova Z, Bakulina A, Garro A, Charlier L, Dumas C, Ventura S, Kajava AV. J Struct Biol. 212(1):107604. Pubmed
  • Point mutations affecting yeast prion propagation change the structure of its amyloid fibrils. A. I. Sulatskayaa, S. A. Bondarev, M. I. Sulatsky, N. P. Trubitsina, M. V.Belousov, G. A. Zhouravleva, M. A. Llanos,[…] Journal of Molecular Liquids. 314, 113618. Pubmed
  • Tally-2.0: upgraded validator of tandem repeat detection in protein sequences. Perovic V, Leclercq JY, Sumonja N, Richard FD, Veljkovic N, Kajava AV. Bioinformatics. 36(10):3260-3262. Pubmed
  • Census of halide-binding sites in protein structures. Skitchenko RK, Usoltsev D, Uspenskaya M, Kajava AV, Guskov A. Bioinformatics. 36(10):3064-3071. Pubmed
  • FTIR Spectroscopy Study of the Secondary Structure Changes in Human Serum Albumin and Trypsin under Neutral Salts. Usoltsev D, Sitnikova V, Kajava A, Uspenskaya M. Biomolecules. 10(4):606. Pubmed
  • Opposite Modulation of RAC1 by Mutations in TRIO Is Associated with Distinct, Domain-Specific Neurodevelopmental Disorders. Barbosa S, Greville-Heygate S, Bonnet M, Godwin A, Fagotto-Kaufmann C, Kajava AV, Laouteouet D, Mawby R, Wai HA, Dingemans AJM, Hehir-Kwa J, Willems M, Capri Y, Mehta SG, Cox H, Goudie D, Vansenne F, Turnpenny P, Vincent M, Cogné B, Lesca G, Hertecant J, Rodriguez D, Keren B, Burglen L, Gérard M, Putoux A; C4RCD Research Group, Cantagrel V, Siquier-Pernet K, Rio M, Banka S, Sarkar A, Steeves M, Parker M, Clement E, Moutton S, Tran Mau-Them F, Piton A, de Vries BBA, Guille M, Debant A, Schmidt S, Baralle D. Am J Hum Genet. pii: S0002-9297(20)30018-5. Pubmed


  • DisProt: intrinsic protein disorder annotation in 2020. Hatos A, Hajdu-Soltész B, Monzon AM, Palopoli N, Álvarez L, Aykac-Fas B, Bassot C, Benítez GI, Bevilacqua M, Chasapi A,[…] Nucleic Acids Res. pii: gkz975. Pubmed
  • Design of a New [PSI +]-No-More Mutation in SUP35 With Strong Inhibitory Effect on the [PSI +] Prion Propagation. Danilov LG, Matveenko AG, Ryzhkova VE, Belousov MV, Poleshchuk OI, Likholetova DV, Sokolov PA, Kasyanenko NA, Kajava AV, Zhouravleva GA, Bondarev SA. Front Mol Neurosci. 12:274. Pubmed
  • Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases. Tørresen OK, Star B, Mier P, Andrade-Navarro MA, Bateman A, Jarnot P, Gruca A, Grynberg M, Kajava AV, Promponas VJ, Anisimova M, Jakobsen KS, Linke D. Nucleic Acids Res. 47(21):10994-11006 Pubmed
  • Prion soft amyloid core driven self-assembly of globular proteins into bioactive nanofibrils. Wang W, Navarro S, Azizyan RA, Baño-Polo M, Esperante SA, Kajava AV, Ventura S. Nanoscale. 11(26):12680-12694. Pubmed
  • Porins and Amyloids are Coded by Similar Sequence Motifs. Villain E, Nikekhin AA, Kajava AV. 19(6):e1800075 Pubmed
  • The HslV Protease from Leishmania major and Its Activation by C-terminal HslU Peptides. Kebe NM, Samanta K, Singh P, Lai-Kee-Him J, Apicella V, Payrot N, Lauraire N, Legrand B, Lisowski V, Mbang-Benet DE, Pages M, Bastien P, Kajava AV, Bron P, Hernandez JF, Coux O. Int J Mol Sci. 20(5). Pubmed


  • Post-Translational Modifications and Diastolic Calcium Leak Associated to the Novel RyR2-D3638A Mutation Lead to CPVT in Patient-Specific hiPSC-Derived Cardiomyocytes. Acimovic I, Refaat MM, Moreau A, Salykin A, Reiken S, Sleiman Y, Souidi M, Přibyl J, Kajava AV, Richard S, Lu JT, Chevalier P, Skládal P, Dvořak P, Rotrekl V, Marks AR, Scheinman MM, Lacampagne A, Meli AC. J Clin Med. 8;7(11) Pubmed
  • Protein Co-Aggregation Related to Amyloids: Methods of Investigation, Diversity, and Classification. Bondarev SA, Antonets KS, Kajava AV, Nizhnikov AA, Zhouravleva GA. Int J Mol Sci. ; 19(8) Pubmed
  • BetaSerpentine: a bioinformatics tool for reconstruction of amyloid structures. Bondarev SA, Bondareva OV, Zhouravleva GA, Kajava AV. Bioinformatics. 34(4):599-608 Pubmed
  • Editorial for special issue « Proteins with tandem repeats: sequences, structures and functions ». Kajava AV, Tosatto SCE. J Struct Biol. 201(2):86-87. Pubmed
  • Identification of the Autochaperone Domain in the Type Va Secretion System (T5aSS): Prevalent Feature of Autotransporters with a β-Helical Passenger. Rojas-Lopez M, Zorgani MA, Kelley LA, Bailly X, Kajava AV, Henderson IR, Polticelli F, Pizza M, Rosini R, Desvaux M. Front Microbiol. 8:2607. Pubmed
  • Establishment of Constraints on Amyloid Formation Imposed by Steric Exclusion of Globular Domains. Azizyan RA, Garro A, Radkova Z, Anikeenko A, Bakulina A, Dumas C, Kajava AV. J Mol Biol. 430(20):3835-3846. Pubmed


  • Classification of β-hairpin repeat proteins. Roche DB, Viet PD, Bakulina A, Hirsh L, Tosatto SCE, Kajava AV. J Struct Biol. pii: S1047-8477(17)30162-4. Pubmed
  • Usage of a dataset of NMR resolved protein structures to test aggregation versus solubility prediction algorithms. Roche DB, Villain E, Kajava AV. Protein Sci. 26(9):1864-1869. Pubmed
  • DisProt 7.0: a major update of the database of disordered proteins. Piovesan D, Tabaro F, Mičetić I, Necci M, Quaglia F, Oldfield CJ, Aspromonte MC, Davey NE, Davidović R, Dosztányi Z,[…] Nucleic Acids Res. 45:D219-D227. Pubmed
  • RepeatsDB 2.0: improved annotation, classification, search and visualization of repeat protein structures. Paladin L, Hirsh L, Piovesan D, Andrade-Navarro MA, Kajava AV, Tosatto SC. Nucleic Acids Res. 45:D308-D312. Pubmed


  • Functional assignment to positively selected sites in the core type III effector RipG7 from Ralstonia solanacearum. Wang K, Remigi P, Anisimova M, Lonjon F, Kars I, Kajava A, Li CH, Cheng CP, Vailleau F, Genin S, Peeters N. Mol Plant Pathol. 17(4):553-64. Pubmed
  • Global genetic diversity of the Plasmodium vivax transmission-blocking vaccine candidate Pvs48/45. Vallejo AF, Martinez NL, Tobon A, Alger J, Lacerda MV, Kajava AV, Arévalo-Herrera M, Herrera S. Malar J. 15:202. Pubmed
  • Tally: a scoring tool for boundary determination between repetitive and non-repetitive protein sequences. Richard FD, Alves R, Kajava AV. Bioinformatics. 32:1952-8. Pubmed
  • α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils. Dearborn AD, Wall JS, Cheng N, Heymann JB, Kajava AV, Varkey J, Langen R, Steven AC. J Biol Chem. 291:2310-8. Pubmed


  • In search of the boundary between repetitive and non-repetitive protein sequences. Richard FD, Kajava AV. Biochem Soc Trans. 43:807-11. Pubmed
  • Restricted mobility of side chains on concave surfaces of solenoid proteins may impart heightened potential for intermolecular interactions. Ramya L, Gautham N, Chaloin L, Kajava AV. Proteins. 83:1654-64. Pubmed
  • Single substitution in bacteriophage T4 RNase H alters the ratio between its exo- and endonuclease activities. Kholod N, Sivogrivov D, Latypov O, Mayorov S, Kuznitsyn R, Kajava AV, Shlyapnikov M, Granovsky I. Mutat Res. 781:49-57. Pubmed
  • Evolution of proteasome regulators in eukaryotes. Fort P, Kajava AV, Delsuc F, Coux O. Genome Biol Evol. 7:1363-79. Pubmed
  • TAPO: A combined method for the identification of tandem repeats in protein structures. Do Viet P, Roche DB, Kajava AV. FEBS Lett. 589:2611-9. Pubmed
  • Structure-based view on [PSI(+)] prion properties. Bondarev SA, Zhouravleva GA, Belousov MV, Kajava AV. Prion. 9:190-9. Pubmed
  • Designs on a curve. Bazan JF, Kajava AV. Nat Struct Mol Biol. 22:103-5. Pubmed
  • A structure-based approach to predict predisposition to amyloidosis. Ahmed AB, Znassi N, Château MT, Kajava AV. Alzheimers Dement. 11:681-90. Pubmed


  • TRDistiller: a rapid filter for enrichment of sequence datasets with proteins containing tandem repeats. Richard FD, Kajava AV. J Struct Biol. 186:386-91. Pubmed
  • Evolutionary link between metazoan RHIM motif and prion-forming domain of fungal heterokaryon incompatibility factor HET-s/HET-s. Kajava AV, Klopffleisch K, Chen S, Hofmann K. Sci Rep. 4:7436. Pubmed
  • Conformational switching in PolyGln amyloid fibrils resulting from a single amino acid insertion. Huang RK1 Baxa U, Aldrian G, Ahmed AB, Wall JS, Mizuno N, Antzutkin O, Steven AC, Kajava AV. Biophys J. 106:2134-42. Pubmed
  • RepeatsDB: a database of tandem repeat protein structures. Di Domenico T, Potenza E, Walsh I, Parra RG, Giollo M, Minervini G, Piovesan D, Ihsan A, Ferrari C, Kajava AV, Tosatto SC. Nucleic Acids Res. 42:D352-7. Pubmed
  • Plasmodium vivax antigen discovery based on alpha-helical coiled coil protein motif. Céspedes N, Habel C, Lopez-Perez M, Castellanos A, Kajava AV, Servis C, Felger I, Moret R, Arévalo-Herrera M, Corradin G, Herrera S. PLoS One. 9:e100440. Pubmed
  • Drosophila Spag is the homolog of RNA polymerase II-associated protein 3 (RPAP3) and recruits the heat shock proteins 70 and 90 (Hsp70 and Hsp90) during the assembly of cellular machineries. Benbahouche Nel H, Iliopoulos I, Török I, Marhold J, Henri J, Kajava AV, Farkaš R, Kempf T, Schnölzer M, Meyer P, Kiss I, Bertrand E, Mechler BM, Pradet-Balade B. J Biol Chem. 289:6236-47. Pubmed
  • Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic domains. Balam S, Olugbile S, Servis C, Diakité M, D’Alessandro A, Frank G, Moret R, Nebie I, Tanner M, Felger I, Smith T, Kajava AV, Spertini F, Corradin G. Malar J. 13:510. Pubmed
  • A structure-based approach to predict predisposition to amyloidosis. Ahmed AB, Znassi N, Château MT, Kajava AV. Alzheimers Dement. 11:681-90. Pubmed


  • Breaking the amyloidogenicity code: methods to predict amyloids from amino acid sequence. Ahmed AB, Kajava AV. FEBS Lett. 587(8):1089-95. Pubmed
  • Antigenicity and immunogenicity of a novel chimeric peptide antigen based on the P. vivax circumsporozoite protein. Céspedes N, Arévalo-Herrera M, Felger I, Reed S, Kajava AV, Corradin G, Herrera S. Vaccine. 31(42):4923-30. Pubmed
  • Effect of charged residues in the N-domain of Sup35 protein on prion [PSI+] stability and propagation. Bondarev SA, Shchepachev VV, Kajava AV, Zhouravleva GA. J Biol Chem. 288(40):28503-13. Pubmed
  • EpCAM controls actomyosin contractility and cell adhesion by direct inhibition of PKC. Maghzal N, Kayali HA, Rohani N, Kajava AV, Fagotto F. Dev Cell. 27(3):263-77. Pubmed


  • Tandem repeats in proteins: from sequence to structure. Kajava AV. J Struct Biol. 179(3):279-88. Pubmed
  • Malaria vaccine development using synthetic peptides as a technical platform. Corradin G, Céspedes N, Verdini A, Kajava AV, Arévalo-Herrera M, Herrera S. Adv Immunol. 114:107-49. Pubmed
  • PRDB: Protein Repeat DataBase. Jorda J, Baudrand T, Kajava AV. Proteomics. 12(9):1333-6. Pubmed
  • Repeat or not repeat?–Statistical validation of tandem repeat prediction in genomic sequences. Schaper E, Kajava AV, Hauser A, Anisimova M. Nucleic Acids Res. 40(20):10005-17. Pubmed
  • Cell biological characterization of the malaria vaccine candidate trophozoite exported protein 1. Kulangara C, Luedin S, Dietz O, Rusch S, Frank G, Mueller D, Moser M, Kajava AV, Corradin G, Beck HP, Felger I. PLoS One. 7(10):e46112. Pubmed


  • Identification of residues within tropomodulin-1 responsible for its localization at the pointed ends of the actin filaments in cardiac myocytes. Tsukada T, Kotlyanskaya L, Huynh R, Desai B, Novak SM, Kajava AV, Gregorio CC, Kostyukova AS. J Biol Chem. 286(3):2194-204. Pubmed
  • Malaria vaccine candidate: design of a multivalent subunit α-helical coiled coil poly-epitope. Olugbile S, Villard V, Bertholet S, Jafarshad A, Kulangara C, Roussilhon C, Frank G, Agak GW, Felger I, Nebie I, Konate K, Kajava AV, Schuck P, Druilhe P, Spertini F, Corradin G. 29(40):7090-9. Pubmed


  • A network of hydrogen bonds on the surface of TLR2 controls ligand positioning and cell signaling. Kajava AV, Vasselon T. J Biol Chem. 2010 285(9):6227-34. Pubmed
  • Beta arcades: recurring motifs in naturally occurring and disease-related amyloid fibrils. Kajava AV, Baxa U, Steven AC. FASEB J. 24(5):1311-9. Pubmed
  • Malaria vaccine: why is it taking so long? Corradin G, Kajava AV. Expert Rev Vaccines. 9(2):111-4. Pubmed
  • Protein tandem repeats – the more perfect, the less structured. Jorda J, Xue B, Uversky VN, Kajava AV. FEBS J. 277(12):2673-82. Pubmed
  • Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex. Pérez-Victoria FJ, Abascal-Palacios G, Tascón I, Kajava A, Magadán JG, Pioro EP, Bonifacino JS, Hierro A. Proc Natl Acad Sci U S A. 107(29):12860-5. Pubmed
  • Protein homorepeats sequences, structures, evolution, and functions. Jorda J, Kajava AV. Adv Protein Chem Struct Biol. 79:59-88. Pubmed
  • Long synthetic peptides for the production of vaccines and drugs: a technological platform coming of age. Corradin G, Kajava AV, Verdini A. Sci Transl Med. 2(50):50rv3. Pubmed


  • The C-terminal domain of Plasmodium falciparum merozoite surface protein 3 self-assembles into alpha-helical coiled coil tetramer. Gondeau C, Corradin G, Heitz F, Le Peuch C, Balbo A, Schuck P, Kajava AV. Mol Biochem Parasitol. 165(2):153-61. Pubmed
  • Sequence conservation in Plasmodium falciparum alpha-helical coiled coil domains proposed for vaccine development. Kulangara C, Kajava AV, Corradin G, Felger I. PLoS One. 4(5):e5419. Pubmed
  • T-REKS: identification of Tandem REpeats in sequences with a K-meanS based algorithm. Jorda J, Kajava AV. Bioinformatics. 25(20):2632-8. Pubmed
  • EtpB is a pore-forming outer membrane protein showing TpsB protein features involved in the two-partner secretion system. Meli AC, Kondratova M, Molle V, Coquet L, Kajava AV, Saint N. J Membr Biol. 230(3):143-54. Pubmed
  • Vaccine potentials of an intrinsically unstructured fragment derived from the blood stage-associated Plasmodium falciparum protein PFF0165c. Olugbile S, Kulangara C, Bang G, Bertholet S, Suzarte E, Villard V, Frank G, Audran R, Razaname A, Nebie I, Awobusuyi O, Spertini F, Kajava AV, Felger I, Druilhe P, Corradin G.  Infect Immun. 77(12):5701-9. Pubmed


  • Three-dimensional structure of canine adenovirus serotype 2 capsid. Schoehn G, El Bakkouri M, Fabry CM, Billet O, Estrozi LF, Le L, Curiel DT, Kajava AV, Ruigrok RW, Kremer EJ. J Virol. 82(7):3192-203. Pubmed
  • Origin and evolution of GALA-LRR, a new member of the CC-LRR subfamily: from plants to bacteria? Kajava AV, Anisimova M, Peeters N. PLoS One. 3(2):e1694. Pubmed
  • Longitudinal analyses of immune responses to Plasmodium falciparum derived peptides corresponding to novel blood stage antigens in coastal Kenya. Agak GW, Bejon P, Fegan G, Gicheru N, Villard V, Kajava AV, Marsh K, Corradin G. Vaccine. 26(16):1963-71. Pubmed

Structural bioinformatics and molecular modelling


Group Leader (Research Director DR1)

Team Members

  • Andrey KAJAVA Chef d'équipe
    (Chercheur DR1) +33 (0)4 34 35 95 38
  • Marie-Therese CHATEAU
    (Maître de conférences) +33 (0)4 34 35 95 39
  • Valentin GONAY
    (Doctorant) +33 (0)4 34 35 95 39
  • Gudrun ALDRIAN
    (IR-Recherche) +33 (0)4 34 35 95 39
  • Stefany NECIOSUP
    (Doctorant) +33 (0)4 34 35 95 39
  • Wissal MEFTAH
    (Stagiaire) +33 (0)4 34 35 95 39
  • Teresa Graciela FERNANDEZ
    (Doctorant) +33 (0)4 34 35 95 39
  • Contact us

    Replace the name and address above with that of the member to contact



    AmyloComp: A Bioinformatic Tool for Prediction of Amyloid Co-aggregation.

    Bondarev SA, Uspenskaya MV, Leclercq J, Falgarone T, Zhouravleva GA, Kajava AV.

    J Mol Biol. 2024 Jan 5:168437.


    Aspartate-phobia of thermophiles as a reaction to deleterious chemical transformations.

    Villain E, Fort P, Kajava AV.

    Bioessays. 2022 Jan;44(1):e2100213.


    Amyloidogenicity as a driving force for the formation of functional oligomers.

    Azizyan RA, Wang W, Anikeenko A, Radkova Z, Bakulina A, Garro A, Charlier L, Dumas C, Ventura S, Kajava AV.

    J Struct Biol. 2020 Oct 1;212(1):107604.